Uncovering hidden protein structures

Combining research-oriented teaching and interdisciplinary collaboration pays off: Researchers at the University of Konstanz develop a novel spectroscopic approach to investigate hitherto difficult-to-observe protein structures. On “campus.kn”, the online magazine of the University of Konstanz, we report on the new approach and its origin at the interface between chemistry and biology.

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New technique for in-cell distance determination

Researchers from the University of Konstanz, Bielefeld University and ETH Zurich demonstrate for the first time that the pulsed EPR technique RIDME (relaxation-induced dipolar modulation enhancement) can be used for in-cell distance determination in biomacromolecules. Applied within the cell, RIDME improves significantly on conventional double electron–electron resonance (DEER) measurements.

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First genetic switch for C. elegans developed

Researchers from the Departments of Biology and Chemistry at the University of Konstanz close a research gap in the field of genetic switches – Development of the first inducible system for C. elegans to switch on genes – Potential medical research applications – Publication in the online journal Nature Communications

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From a plant sugar to toxic hydrogen sulfide

In a doctoral research project conducted at the Department of Biology, the degradation of the dietary sugar sulfoquinovose by anaerobic bacteria to toxic hydrogen sulfide was described for the first time – increased production of hydrogen sulfide in the human intestinal system has been associated with inflammatory bowel disease and colon cancer.

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