Ein molekularer Mechanismus aufgeschlüsselt. Abbildung: Aswin Mangerich, University of Konstanz

When the "guardian" and the "caretaker" of the genome join forces

Scientists from Konstanz, Ulm and Karlsruhe decipher a biochemical mechanism significant for tumour biology

Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance for the development of cancer and the fight against that disease. Particularly important is the interaction between the tumour-suppressor protein p53, known as the "guardian of the genome", and the enzyme PARP-1, the "caretaker of the genome". The research project was carried out in collaboration with the University of Ulm and the Karlsruhe Institute of Technology (KIT), and the findings were published in the prestigious scientific journal Nucleic Acids Research (NAR) on 25 January 2018. Read more...