Bold: Doctoral researchers of KoRS-CB

Slash: First-authorship by more than one person (equal constribution) is indicated by a slash between the names


Altaner S, Jaeger S, Fotler R, Zemskov I, Wittmann V, Schreiber F, Dietrich DR (2019): Machine learning prediction of cyanobacterial toxin (microcystin) toxicodynamics in humans. ALTEX 36, 2

Altaner S, Puddick J, Fessard V, Feurstein D, Zemskov I, Wittmann V, Dietrich DR (2019): Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC- ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards. Toxins (Basel) 11, 7

Baade T, Paone C, Baldrich A, Hauck CR (2019): Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interaction. Sci Rep 9, 1, 5728

Bastek H, Zubel T, Stemmer K, Mangerich A, Beneke S, Dietrich DR (2019): Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models. Toxicology 420, 29-38

Braun T, Drescher M, Summerer D (2019): Expanding the Genetic Code for Site-Directed Spin-Labeling. Int J Mol Sci 20, 2

Finke A, Schneider AK, Spreng AS, Leist M, Niemeyer CM, Marx A (2019): Functionalized DNA Hydrogels Produced by Polymerase-Catalyzed Incorporation of Non-Natural Nucleotides as a Surface Coating for Cell Culture Applications. Adv Healthc Mater 8, e1900080

Hassenrück J, Wittmann V (2019): Cyclopropene derivatives of aminosugars for metabolic glycoengineering. Beilstein J Org Chem 15, 584-601

Höfel S, Fix MK, Zwicker F, Sterpin E, Drescher M (2019): EPR imaging of magnetic field effects on radiation dose distributions around millimeter-size air cavities. Phys Med Biol 64,  175013

Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF (2019): Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7. Int J Mol Sci 20, 10

Junghare M, Spiteller D, Schink B (2019): Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans. ISME J 13, 5, 1252-1268

Keller A, Schink B and Müller N (2019): Alternative Pathways of Acetogenic Ethanol and Methanol Degradation in the Thermophilic Anaerobe Thermacetogenium phaeum. Front Microbiol 10, 423

Kisitu J, Hougaard Bennekou S, Leist M (2019): Chemical Concentrations in Cell Culture Compartments (C5) : Cconcentration Definitions. ALTEX, 36, 1, p.154-160

Kropp HM, Diederichs K, Marx A (2019): The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide. Angew Chem Int Ed Engl 58, 16, 5457-5461

Krüger A, Stier A, Fischbach A, Burkle A, Hauser K, Mangerich A (2019): Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy. Nucleic Acids Res 47, 9, 4843-4858

Kugele A, Braun TS, Widder P, Williams L, Schmidt MJ, Summerer D, Drescher M (2019): Site-directed spin labelling of proteins by Suzuki-Miyaura coupling via a genetically encoded aryliodide amino acid. Chem Commun 55, 13, 1923-1926

Kugele A, Silkenath B, Langer J, Wittmann V, Drescher M (2019): Protein Spin Labeling with a Photocaged Nitroxide Using Diels-Alder Chemistry. Chem Bio Chem

Li J, Koerner J, Basler M, Brunner T, Kirk CJ, Groettrup M (2019): Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors. Kidney Int 95, 3, 611-623

Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D (2019): A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia. PNAS Feb 2019, 201815661

Sack M, Stifel J, Kreft SG, Deuerling E, Hartig JS (2019): Neomycin-dependent hammerhead ribozymes for the direct control of gene expression in Saccharomyces cerevisiae. Methods 161, 35-40

Schart VF, Hassenrück J, Späte AK, Dold JEGA, Fahrner R, Wittmann V  (2019): Triple Orthogonal Labeling of Glycans by Applying Photoclick Chemistry. Chem Bio Chem, 20, 2: 166-171

Schober AF, Ri OBRC, Bischoff A, Lepetit B, Gruber A, Kroth PG (2019): Organelle Studies and Proteome Analyses on Mitochondria and Plastids Fractions from the Diatom Thalassiosira pseudonana. Plant Cell Physiol

Shen K, Gamerdinger M, Chan R, Gense K, Martin EM, Sachs N, Knight PD, Schlomer R, Calabrese AN, Stewart KL, Leiendecker L, Baghel A, Radford SE, Frydman J, Deuerling E (2019): Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies. Mol Cell 74, 4, 729-741 e727

Szamosvári D, Schuhmacher T, Hauck CR, Böttcher T (2019): A thiochromenone antibiotic derived from the Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis. Chemical Science, 10, 6624-6628

Thiel J, Byrne JM, Kappler A, Schink B, Pester M (2019): Pyrite formation from FeS and H2S is mediated through microbial redox activity. Proc Natl Acad Sci U S A 116, 14, 6897-6902

Widder P, Berner F, Summerer D, Drescher M (2019): Double Nitroxide Labeling by Copper-Catalyzed Azide-Alkyne Cycloadditions with Noncanonical Amino Acids for Electron Paramagnetic Resonance Spectroscopy. ACS Chem Biol 14, 5, 839-844

Wurmthaler LA, Sack M, Gense K, Hartig JS, Gamerdinger M (2019): A tetracycline-dependent ribozyme switch allows conditional induction of gene expression in Caenorhabditis elegans. Nat Commun 10, 1, 491

Zhao X, Missun M, Schneider T, Muller F, Lutz J, Scheffner M, Marx A, Kovermann M (2019): Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy. Chem Bio Chem, 20, 1-7

Ganz M, Vogel C, Czada C, Jörke V, Gwosch EC, Kleiner R, Pierzynska-Mach A, Zanacchi FC, Diaspro A, Kappes F, Bürkle A, Ferrando-May E. The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. PLoS One. 14:e0213130 (2019)


Aichem A, Anders S, Catone N, Rossler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schutz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M, Wiesner S (2018): The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat Commun 9, 1, 3321

Aschenbrenner J, Werner S, Marchand V, Adam M, Motorin Y, Helm M, Marx A (2018): Engineering of a DNA Polymerase for Direct m6A Sequencing. Angew Chem Int Ed, 57, 2, 417-421

Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Langrish CL, Groettrup M (2018): Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep, Oct 2, pii: e46512

Basler M, Maurits E, de Bruin G, Koerner J, Overkleeft HS, Groettrup M (2018): Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome. Br J Pharmacol 175, 1, 38-52

Basler M, Mundt S, Groettrup M (2018): The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. Eur J Immunol 48, 3, 419-429

Berg A, Kukharenko O, Scheffner M, Peter C (2018): Towards a molecular basis of ubiquitin signaling: A dual-scale simulation study of ubiquitin dimers. PLoS Comput Biol, 14, 11,  e1006589

Bucher KS,Yan H, Creutznacher R, Ruoff K, Mallagaray A, Grafmuller A, Dirks JS, Kilic T, Weickert S, Rubailo A, Drescher M, Schmidt S, Hansman G, Peters T, Uetrecht C, Hartmann L (2018): Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein. Biomacromolecules, 19, 9: 3714-3724

Burrichter A, Denger K, Franchini P, Huhn T, Müller N, Spiteller D, Schleheck D (2018): Anaerobic Degradation of the Plant Sugar Sulfoquinovose Concomitant With H2S Production: Escherichia coli K-12 and Desulfovibrio sp. Strain DF1 as Co-culture Model. Front Microbiol, 9,  2792

de Souza-Fagunes EM, Delp J, Prazeres PHDM, Bonfirm Marques L, LinoCarmo AM, Fazza Stroppa PH, Glanzmann N, Kisitu J, Szamosvari D, Böttcher T, Leist M, da Silva AD (2018): Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties. Chem Biol Interact, 291, p.253-263

Dhodary B, Schilg M, Wirth R, Spiteller D (2018): Secondary Metabolites from Escovopsis weberi and Their Role in Attacking the Garden Fungus of Leaf‐Cutting Ants. Chemistry 20, 24, 17,  4445-4452

Doll F, Hassenrück J, Wittmann V, Zumbusch A (2018): Intracellular Imaging of Protein-Specific Glycosylation. In: Imperiali B: Methods in Enzymology, Elsevier, 598: 283-319

Fischbach A, Kruger A, Hampp S, Assmann G, Rank L, Hufnagel M, Stockl MT, Fischer JMF, Veith S, Rossatti P, Ganz M, Ferrando-May E, Hartwig A, Hauser K, Wiesmuller L, Burkle A, Mangerich A (2018): The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1. Nucleic Acids Res 46, 2, 804-822

Gutbier S, Spreng AS, Delp J, Schildknecht S, Karreman C, Suciu I, Brunner T, Groettrup M, Leist M (2018): Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress. Cell Death Differ, 25:2101-2117

Hammler D, Marx A, Zumbusch A (2018): Fluorescence-Lifetime-Sensitive Probes for Monitoring ATP Cleavage. Chemistry 24, 57, 15329-15335

Heim A, Tischer T, MAyer TU (2018): Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20. EMBO Rep, 19, 12

Hess SK, Lepetit B, Kroth PG, Mecking S (2018): Production of Chemicals from Microalgae Lipids - Status and Perspectives. E J Lipid Sci Technol 119, 1700152

Jaeger S, Fulle S, Turk S (2018): Mol2vec: Unsupervised Machine Learning Approach with Chemical Intuition. J Chem Inf Model, 58, 1, 27-35

Jorgensen AS, Adogamhe PE, Laufer JM, Legler DF, Veldkamp CT, Rosenkilde MM, Hjorto GM (2018): CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells. J Leukoc Biol 104, 2, 401-411

Knorr S / Sinn M, Galetskiy D, Williams RM, Wang C, Müller N, Mayans O, Schleheck D, Hartig JS (2018): Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nature Communications. Nat Commun, 9, 1:5071

Köhn B, Kovermann M (2018): Macromolecular crowding tunes protein stability by manipulating solvent accessibility. Chem Bio Chem  10.1002/cbic.201800679

Köhn B, Shanmugavel KP, Wu M, Kovermann M, Wittung-Stafshede P (2018): A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity. Biophys J, 115, 6:1007-1018

Kropp HM, Durr SL, Peter C, Diederichs K, Marx A (2018): Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. Proc Natl Acad Sci U S A 115, 40, 9992-9997

Krüger A, Bürkle A, Mangerich A, Hauser K (2018): A combined approach of surface passivation and specific immobilization to study biomolecules by ATR-FTIR spectroscopy1. Biomedical Spectroscopy and Imaging 7, 1-2, 25-33

Laufer JM, Kindinger I, Artinger M, Pauli A, Legler DF (2018): CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70. Front Immunol 9, 3115

Laufer JM, Legler DF (2018): Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions. J Leukoc Biol 104, 2, 301-312

Laufer JM, Lyck R, Legler DF (2018): ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins. FASEB J 32, 9, 4824-4835

Maier MY, Luks L, Baudendistel OR, Wittmann V, Dietrich DR (2018): Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy. Chem Biol Interact, 281:69-80

Muck CS, Linseis M, Welte H, Weickert S, Drescher M, Winter RF (2018): Electrochemical and Spectroscopic Studies on σ-Phenyl Ruthenium Complexes Ru(CO)Cl(C6H4R-4)(PiPr3)2. Organometallics 37, 13, 2111-2122

Nyffeler J, Chovancova P, Dolde X, Holzer AK, Purvanov V, Kindinger I, Kerins A, Higton D, Silvester S, van Vugt-Lussenburg BMA, Glaab E, van der Burg B, Maclennan R, Legler DF, Leist M (2018): A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins. Arch Toxicol 92, 3, 1225-1247

Purvanov V, Matti C, Samson GPB, Kindinger I, Legler DF (2018): Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions. Int J Mol Sci 19, 12

Roser P, Weisner J, Simard JR, Rauh D, Drescher M (2018): Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α. Chem Commun, 54, 85:12057-12060

Rossy J, Laufer JM, Legler DF (2018): Role of Mechanotransduction and Tension in T Cell Function. Front Immunol 9, 2638

Rütschlin S, Böttcher T (2018): Dissecting the mechanism of oligomerization and macrocyclization reactions of NRPS independent siderophore synthetases. Chemistry, 24: 16044-16051

Rütschlin S, Böttcher T (2018): Eine vielseitige Enzymklasse für die Synthese ringförmiger Siderophore. BIOspektrum 05.18: 484-487

Rütschlin S, Gunesch S, Böttcher T (2018): One Enzyme to Build Them All – Ring-Size Engineered Siderophores Inhibit Swarming Motility of Vibrio. ACS Chem Biol, 13, 5, 1153-1158

Sailer C, Offensperger F, Julier A, Kammer KM, Walker-Gray R, Gold MG, Scheffner M, Stengel F (2018): Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex. Nat Commun, 9, 1:4441

Schmalz MF, Wieser I, Schindler F, Czada C, Leitenstorfer A, Ferrando-May E (2018): Highly standardized multicolor femtosecond fiber system for selective microphotomanipulation of deoxyribonucleic acid and chromatin. Opt Lett 15, 43, 12:2877-2880

Schmidt C, Berger T, Groettrup M, Basler M (2018): Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis. Front Immunol, 9, 2386, 1664-3224

Schober AF, Flori S, Finazzi G, Kroth PG, Bártulos CR (2018): Isolation of Plastid Fractions from the Diatoms Thalassiosira pseudonana and Phaeodactylum tricornutum. In: Maréchal E. (eds) Plastids. Methods in Molecular Biology, 1829: 189-203

Schregle R, Mah MM, Mueller S, Aichem A, Basler M, Groettrup M (2018): The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions. Immunogenetics 70, 7, 429-438

Szamosvári D / Rütschlin S, Böttcher T (2018): From pirates and killers: Does metabolite diversity drive bacterial competition? Org Biomol Chem, 16, 2814-2819

Voggel M, Meinusch RM, Siewert V, Kunkel M, Wittmann V, Polarz S (2018): Sweet surfactants: packing parameter-invariant amphiphiles as emulsifiers and capping agents for morphology control of inorganic particles. Soft Matter 14, 35, 7214-7227

Weickert S, Cattani J, Drescher M (2018): Intrinsically disordered proteins (IDPs) studied by EPR and in-cell EPR. Electron Paramagnetic Resonance, 26: 1-37

Weickert S, Seitz T, Myers WK, Timmel CR, Drescher M, Wittmann V (2018): Conformationally Unambiguous Spin Label for Exploring the Binding Site Topology of Multivalent Systems. J Phys Chem Lett, 9, 20: 6131-6135

Winter P, Borgelt C, Berthold MR (2018): Learned Feature Generation for Molecules. In: Duivesteijn W., Siebes A., Ukkonen A. (eds) Advances in Intelligent Data Analysis XVII, Springer, 380-391

Wurmthaler LA, Klauser B, Hartig JS (2018): Highly motif- and organism-dependent effects of naturally occurring hammerhead ribozyme sequences on gene expression. RNA Biol, 15, 2:231-241

Yushchenko T, Deuerling E, Hauser K (2018): Insights into the Aggregation Mechanism of PolyQ Proteins with Different Glutamine Repeat Lengths. Biophys J 114, 8, 1847-1857


Aschenbrenner J, Marx A (2017): DNA polymerases and biotechnological applications. Curr Opin Biotechnol, 48, 187-195

Berg A, Peter C, Johnston K (2017): Evaluation and Optimization of Interface Force Fields for Water on Gold Surfaces. J Chem Theory Comput, 13, 11, 5610-5623

Betz K, Kimoto M, Diederichs K, Hirao I, Marx A (2017): Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Angew Chem Int Ed Engl 56, 39, 12000-12003

Betz K, Nilforoushan A, Wyss LA, Diederichs K, Sturla SJ, Marx A (2017): Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. Chem Commun (Camb) 53, 94, 12704-12707

Bleicken S, Hantusch A, Das KK, Frickey T, Garcia-Saez AJ (2017): Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of a complexes for apoptosis regulation. Nat Commun 8, 73

Chovancova P, Merk V, Marx A, Leist M, Kranaster R (2017): Reverse-transcription quantitative PCR directly from cells without RNA  extraction and without isothermal reverse-transcription: a ‘zero-step’ RT-qPCR  protocol. Biology Methods and Protocols 2, 1

Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Caucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B (2017): Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4. FASEB J 2017, 31, 7, 3084-3097

Dold JEGA, Pfotzer J, Späte AK, Wittmann V (2017): Dienophile-Modified Mannosamine Derivatives for Metabolic Labeling of Sialic Acids: A Comparative Study. Chem Bio Chem 2017, 18, 1242-1250

Ermert S, Hacker SM, Buntru A, Scheffner M, Hauck CR, Marx A (2017): Different Enzymatic Processing of γ-Phosphoramidate and γ-Phosphoester-Modified ATP Analogues. Chem Bio Chem 2017, 18, 378-381

Ermert S, Marx A, Hacker SM (2017): Phosphate-Modified Nucleotides for Monitoring Enzyme Activity. Top Churr Chem (Z) 2017, 375, 28

Fallah MA, Gerding HR, Scheibe C, Drescher M, Karreman C, Schildknecht S, Leist M, Hauser K (2017): Simultaneous IR-Spectroscopic Observation of alpha-Synuclein, Lipids, and Solvent Reveals an Alternative Membrane-Induced Oligomerization Pathway. Chem Bio Chem 18, 23, 2312-2316

Fillbrunn A, Dietz C, Pfeuffer J, Rahn R, Landrum GA, Berthold MR (2017): KNIME for reproducible cross-domain analysis of life science data. J Biotech, 261: 149-156

Fillbrunn A, Wörteler L, Grossniklaus M, Berthold MR (2017): Bucket Selection : A Model-Independent Diverse Selection Strategy for Widening. In: Adams N,  Tucker A, Weston D (Hrsg.): Advances in Intelligent Data Analysis XVI Proceedings , 10584: 87-98

Flori S, Jouneau PH, Bailleul B, Gallet B, Estrozi LF, Moriscot C, Bastien O, Eicke S, Schober A, Río Bártulos C, Maréchal E, Kroth PG, Petroutsos D, Zeeman S, Breyton C, Schoehn G, Falconet D, Finazzi G (2017): Plastid thylakoid architecture optimizes photosynthesis in diatoms. Nat Commun, 8, 15885

Goetz KH, Hacker SH, Mayer D, Dürig JN, Stenger S, Marx A (2017): Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis. ACS Chem Biol, 12, 10, 2682-2689

Grabinger T, Bode KJ, Demgenski J, Seitz C, Delgado ME, Kostadinova F, Reinhold C, Etemadi N, Wilhelm S, Schweinlin M, Hanggi K, Knop J, Hauck C, Walles H, Silke J, Wajant H, Nachbur U, W WW-L, Brunner T (2017): Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells. Gastroenterology 152, 4, 867-879

Hantusch A, Brunner T, Frickey T, Rehm M (2017): Bcl-2-Ome – a database and interactive web service for dissecting the Bcl-2 interactome.  Cell Death Differ 24, 192

Heim A, Rymarczyk B, Mayer TU (2017): Regulation of Cell Division. In: Pelegri F, Danilchik M, Sutherland A: Vertebrate Development: Maternal to Zygotic Control, Adv Exp Med Biol, 953, 83-116

Hess SK, Schunck NS, Goldbach V, Ewe D, Kroth PG, Mecking S (2017): Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach. J Am Chem Soc, 2017, 139, 38, 13487–13491

Hirsch C, Striegl B, Mathes S, Adlhart C, Edelmann M, Bono E,Gaan S, Salmeia KA, Hoelting L, Krebs A, Nyffeler J, Pape R, Bürkle A, Leist M, Wick P, Schildknecht S (2017): Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants. Arch Toxicol, 91, 1:407-425

Hottin A, Betz K, Diederichs K, Marx A (2017): Structural Basis for the KlenTaq DNA Polymerase Catalysed Incorporation of Alkene- versus Alkyne-Modified Nucleotides. Chemistry 23, 9, 2109-2118

Koerner J, Brunner T, Groettrup M (2017): Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice. Oncotarget, 8, 31, 50873-50888

Kropp H, Betz K, Wirth J, Diederichs K, Marx A (2017): Crystal structures of ternary complexes of archaeal B-family DNA polymerases. PLoS One, 12, 12, e0188005

Lange S, Hacker SM, Schmid P, Scheffner M, Marx A (2017):Small-Molecule Inhibitors of the Tumor Suppressor Fhit. Chem Bio Chem, 18, 1707-1711

Legler DF, Matti C, Laufer JM, Jakobs BD, Purvanov V, Uets-von Almen E, Thelen M (2017): Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention. Mol Pharmacol, 91, 4, 331-338

Luks L / Maier MY, Sacchi S, Pollegioni L, Dietrich DR (2017): Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy. Chem Biol Interact, 281, 69-80

Moeckel MM, Heim A, Tischer T, Mayer TU (2017): Xenopus laevis Kif18A is a highly processive kinesin required for meiotic spindle integrity. Biol Open, 15, 6, 4, 463-470

Mundt S, Basler M, Sawitzki B, Groettrup M (2017): No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Mol Immunol 88, 32-37

Qiang Y, Wang WF, Dhodary B, Yang JL (2017): Zeolitic imidazolate framework 8 (ZIF-8) reinforced macroporous resin D101 for selective solid-phase extraction of 1-naphthol and 2-naphthol from phenol compounds. Electrophoresis, 38, 13-14, 1685-1692

Robotta M, Cattani J, Martins JC, Subramaniam V, Drescher M (2017): Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding. J Am Chem Soc 139, 12, 4254-4257

Rütschlin S, Gunesch S, Böttcher T (2017): One Enzyme, Three Metabolites: Shewanella algae Controls Siderophore Production via the Cellular Substrate Pool. Cell Chem Biol, 24, 5, 598-604.e10

Schink B, Montag D, Keller A, Müller N (2017): Hydrogen or formate: Alternative key players in methanogenic degradation. Environmental Microbiology Reports, 9, 189-202

Sommershof A, Scheuermann L, Koerner J, Groettrup M (2017): Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma. Brain Behav Immun, 65, 140-149

Wallrodt S, Simpson EL, Marx A (2017): Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues.  Beilstein J Org Chem 13, 495–501

Zemskov I, Altaner S, Dietrich DR, Wittmann V (2017): Total Synthesis of Microcystin-LF and Derivatives Thereof. J Org Chem 82, 7, 3680-3691

Zhao X, Lutz J, Höllmüller E, Scheffner M, Marx A, Stengel F (2017): Identification of Proteins Interacting with Ubiquitin Chains. Angew Chem Int Ed 56, 15764-15768


Apell H-J, Damnjanovic B (2016): Assaying P-Type ATPases Reconstituted in Liposomes. In: Bublitz M: P-Type ATPase : Methods and Protocols Humana Press, 127-156

Aschenbrenner J, Marx A (2016): Direct and site-specific quantification of RNA 2′-O-methylation by PCR with an engineered DNA polymerase. Nucleic Acids Res 44, 8, 3495-3502

Assmann G, Brehm W, Diederichs K (2016): Identification of rouge datasets in serial crystallography. J Appl Crystallogr 49, 3, 1021–1028

Baudendistel OR / Wieland DE, Schmidt MS, Wittmann V (2016): Real-Time NMR Studies of Oxyamine Ligations of Reducing Carbohydrates under Equilibrium Conditions. Chem Eur J, 2016.22, 17359-17365

Beshr G, Sommer R, Hauck D, Siebert DCB, Hofmann A, Imberty A, Titz A (2016): Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors. Med Chem Comm 7, 3, 519-530

Buntz A / Wallrodt S, Gwosch E, Schmalz M, Beneke S, Ferrando-May E, Marx A, Zumbusch A (2016):Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation. Angew Chem Int Ed 55, 27, 11256–11260

Chang EP, Perovic I, Rao A, Cölfen H, Evans JS (2016): Insect Cell Glycosylation and Its Impact on the Functionality of a Recombinant Intracrystalline Nacre Protein, AP24. Biochemistry 55, 7, 1024-1035

Doll F / Buntz A, Späte A-K, Schart VF, Timper A, Schrimpf W, Hauck CR, Zumbusch A, Wittmann V (2016): Visualization of Protein-Specific Glycosylation inside Living Cells. Angew Chem Int Ed 55, 6, 2262-2266

Efremova L, Chovancova P, Adam M, Gutbier S, Schildknecht S, Leist M (2016): Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation. Arch Toxicol 1-16

Felletti M, Bieber A, Hartig JS (2016): The 3' -untranslated region of MPNAs as a site for ribozymes cleavage-dependent processing and control in bacteria. RNA Biol 14(11), 1522-1533

Felletti M, Hartig JS (2016): Ligand-dependent ribozymes. Wiley Interdiscip Rev RNA, 8, 2

Felletti M, Klauser B, Hartig JS (2016): Screening of Genetic Switches Based on the Twister Ribozyme Motif. In: Mayer G: Nucleic acid aptamers: selection, characterization, and application Humana Press, 225-239

Felletti M, Stifel J, Wurmthaler LA, Geiger S, Hartig JS (2016): Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nature Commun, 7, 12834

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Nikolay R / Schmidt S, Schlömer R, Deuerling E, Nierhaus KH (2016): Ribosome Assembly as Antimicrobial Target. Antibiotics (Basel) 5

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Rohse P, Wittmann V (2016): Mechanistic Insight into Nanomolar Binding of Multivalent Neoglycopeptides to Wheat Germ Agglutinin. Chem Eur J 22, 28, 9724–9733

Roser P, Schmidt MJ, Drescher M, Summerer D (2016): Site-directed spin labeling of proteins for distance measurements in vitro and in cells. Org Biomol Chem 14, 5468-5476

Schneider D / Schneider T, Aschenbrenner J, Mortensen F, Scheffner M, Marx A (2016): Anionic surfactants enhance click reaction-mediated protein conjugation with ubiquitin. Bioorgan Med Chem 24, 5, 995-1001

Schneider F, Zhao T, Huhn T (2016): Cytotoxic Heteroleptic Heptacoordinate Salan Zirconium(IV)-bis-Chelates – Synthesis, Aqueous Stability and X-ray Structure Analysis. Chem Commun, 52, 66

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Uraban JM, Holder I, Schmidt M, Fernandez Espin V, Garcia de la Torre J, Hartig J, Cölfen H (2016): Shape Analysis of DNA-Au Hybrid Particles by Analytical Ultracentrifugation. ACS Nano, 10, 8:7418-27

Verga D, Welter M, Marx A (2016): Sequence selective naked-eye detection of DNA harnessing extension of oligonucleotide-modified nucleotides. Bioorg Med Chem Lett 26, 3, 841-844

Wallrodt S, Buntz A, Wang Y, Zumbusch A, Marx A (2016): Bioorthogonally Functionalized NAD+ Analogues for In-Cell Visualization of Poly(ADP-Ribose) Formation. Angew Chem Int Ed 55, 27, 7660–7664

von Watzdorf J / Leitner K, Marx A (2016): Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5-Methylcytosine. Angew Chem Int Ed 55, 9, 3229-3232

Weickert S, Drescher M (2016): Electron Paramagnetic Resonance Spectroscopy. In: Wang Z, Willie U, Juaristi E: Encyclopedia of Physical Organic Chemistry, Wiley Sons, 2911-2956

Welter M, Verga D, Marx A (2016): Sequence-Specific Incorporation of Enzyme-Nucleotide Chimera by DNA Polymerase. Angew Chem Int Ed 55, 10131-10135

Wierer S, Daldrop P, Ahmad MUD, Boos W, Drescher M, Welte W, Seidel R (2016): TrmBL2 from Pyrococcus furiosus Interacts Both with Double-Stranded and Single-Stranded DNA. PLoS ONE, 11, 5, e0156098


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Basler M, Buerger S, Groettrup M (2015): The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense. Mol Immunol 68, 2 Pt A, 129-132

Basler M, Mundt S, Bitzer A, Schmidt C, Groettrup M (2015): The immunoproteasome: a novel drug target for autoimmune diseases. Clin Exp Rheumatol 33, 4 Suppl 92, S74-79

Beato C, Fernández MS, Fermani S, Reggi M, Neira-Carrillo A, Rao A, Falini G, Arias JL (2015): Calcium carbonate crystallization in tailored constrained environments. CrystEngComm 17, 5953-5961

Bialas J, Groettrup M, Aichem A (2015): Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation. PLoS ONE 10, 3, e0120329

Braun J, Möckel MM, Strittmatter T, Marx A, Groth U, Mayer TU (2015): Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A. ACS Chemical Biology 10, 2, 554-560

Brockmann A, Bluwstein A, Kogel A, May S, Marx A, Tschan MP, Brunner T (2015): Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation. Cell Death & Disease 6, e1778

Bürger S, Herrmann VL, Mundt S, Trautwein N, Groettrup M, Basler M (2015): The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. J Immunol 195, 9, 4106-4116

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Hacker SM, Buntz A, Zumbusch A, Marx A (2015): Direct Monitoring of Nucleotide Turnover in Human Cell Extracts and Cells by Fluorogenic ATP Analogs. ACS Chemical Biology 10, 11, 2544-2552

Hacker SM, Welter M, Marx A (2015): Synthesis of γ-Phosphate-Labeled and Doubly Labeled Adenosine Triphosphate Analogs. Curr Protoc Nucleic Acid Chem 60, 13, 14, 11-25

Heim A, Konietzny A, Mayer TU (2015): Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit. EMBO Rep 16, 11, 1501-1510

Hofmann A / Sommer R, Hauck D, Stifel J, Göttker-Schnetmann I, Titz A (2015): Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa. Carbohyd Res 412, 34-42

Holder IT, Wagner S, Xiong P, Sinn M, Frickey T, Meyer A, Hartig JS (2015): Intrastrand triplex DNA repeats in bacteria : a source of genomic instability. Nucleic Acids Res 43, 21, 10126-10142

Hubrich F, Juneja P, Müller M, Diederichs K, Welte W, Andexer JN (2015): Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold. J Am Chem Soc 137, 34, 11032-11037

Junghare M, Patil Y, Schink B (2015): Draft genome sequence of a nitrate-reducing, o-phthalate degrading bacterium, Azoarcus sp. strain PA01T. Standards in Genomic Sciences 10, 90

Junghare M, Schink B (2015): Desulfoprunum benzoelyticum gen. nov., sp. nov., a Gram-negative benzoate-degrading sulfate-reducing bacterium isolated from the wastewater treatment plant. Int J Syst and Evol Micr 65, 1, 77-84

Kang JH, Manousaki T, Franchini P, Kneitz S, Schartl M, Meyer A (2015): Transcriptomics of two evolutionary novelties: how to make a sperm-transfer organ out of an anal fin and a sexually selected “sword” out of a caudal fin. Ecology and Evolution 5, 4, 848–864

Kastl J, Braun J, Prestel A, Möller H, Huhn T, Mayer TU (2015): Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein–Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chemical Biology 10, 7, 1661–1666

Klauser B, Rehm C, Summerer D, Hartig JS  (2015): Chapter Fifteen - Engineering of Ribozyme-Based Aminoglycoside Switches of Gene Expression by In Vivo Genetic Selection in Saccharomyces cerevisiae. In:  Donald HB-A: Methods in Enzymology Academic Press, 301-320.

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Kubik G, Summerer D (2015): Deciphering epigenetic cytosine modifications by direct molecular recognition. ACS Chemical Biology 10, 7, 1580-1589

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Mortensen F, Schneider D, Barbic T, Sladewska-Marquardt A, Kühnle S, Marx A, Scheffner M (2015): Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination. P Natl Acad Sci USA 112, 32, 9872-9877

Mundt S, Groettrup M, Basler M (2015): Analgesia in mice with experimental meningitis reduces pain without altering immune parameters. Altex-Altern Tierexp 32, 3, 183-189

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Patil Y, Junghare M, Pester M, Muller N, Schink B (2015): Anaerobium acetethylicum gen. nov., sp. nov., a strictly anaerobic, gluconate-fermenting bacterium isolated from a methanogenic bioreactor. Int J Syst Evol Microbiol 65, 10, 3289-3296

Preissler S / Reuther J, Koch M, Scior A, Bruderek M, Frickey T, Deuerling E (2015): Not4-dependent translational repression is important for cellular protein homeostasis in yeast. EMBO J 34, 12, 1905-1924

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Rao A, Fernández MS, Cölfen H, Arias JL (2015): Distinct Effects of Avian Egg Derived Anionic Proteoglycans on the Early Stages of Calcium Carbonate Mineralization. Cryst Growth Des 15, 5, 2052-2056

Rehm C, Klauser B, Hartig JS (2015): Engineering Aptazyme Switches for Conditional Gene Expression in Mammalian Cells Utilizing an In Vivo Screening Approach. In: Ponchon L: RNA Scaffolds: Methods and Protocols Springer New York, 127-140.

Rehm C, Wurmthaler LA, Li Y, Frickey T, Hartig JS (2015): Investigation of a Quadruplex-Forming Repeat Sequence Highly Enriched in Xanthomonas and Nostoc sp. PLoS ONE 10, 12, e0144275

Rempel E, Hoelting L, Waldmann T, Balmer NV, Schildknecht S, Grinberg M, Das Gaspar JA, Shinde V, Stober R, Marchan R, van Thriel C, Liebing J, Meisig J, Bluthgen N, Sachinidis A, Rahnenfuhrer J, Hengstler JG, Leist M (2015): A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol 89, 9, 1599-1618

Rösner D, Schneider T, Schneider D, Scheffner M, Marx A (2015): Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation. Nat Protoc 10, 10, 1594-1611

Schildknecht S / Pape R, Meiser J, Karreman C, Strittmatter T, Odermatt M, Cirri E, C, Friemel A, Ringwald M, Pasquarelli N, Ferger B, Brunner T, Andreas M, Möller H, Hiller K, Leist M (2015): Preferential extracellular generation of the active parkinsonian toxin MPP+ by transporter-independent export of the intermediate MPDP+. Antidoxid Redox Sign 23, 13, 1001-1016

Schmidt MJ, Fedoseev A, Bücker D, Borbas J, Peter C, Drescher M, Summerer D (2015): EPR Distance Measurements in Native Proteins with Genetically Encoded Spin Labels. ACS Chemical Bioligy 10, 2764-2771

Schmidt MJ, Fedoseev A, Summerer D, Drescher M (2015): Chapter Eighteen - Genetically Encoded Spin Labels for In Vitro and In-Cell EPR Studies of Native Proteins. Method Enzymol 563, 483 - 502

Schneider T, Schneider D, Marx A, Scheffner M (2015): Analyse des „Ubiquitin-Codes“ mithilfe Protease-resistenter Ubiquitinketten. BioSpektrum 21, 4, 384-384

Seitz T, Fleck C, Wittmann V  (2015): Short Synthesis of (2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-d-glucopyranosyl)benzene and 4-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-d-glucopyranosyl)bromobenzene. In: Roy Rea: Carbohydrate Chemistry: Proven Synthetic Methods CRC Press, 219-226.

Seitz T, Maierhofer C, Matzner D, Wittmann V  (2015): 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-O-p-nitrophenoxycarbonyl-α-d-glucopyranose. In: Roy Rea: Carbohydrate Chemistry: Proven Synthetic Methods CRC Press, 215-218.

Sommer R, Hauck D, Varrot A, Wagner S, Audfray A, Prestel A, Möller H, Imberty A, Titz A (2015): Cinnamide Derivatives of D-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa. ChemistryOpen 4, 6, 756-767

Verga D, Welter M, Steck A-L, Marx A (2015): DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme. Chem Commun 51, 34, 7379-7381

Windler M, Leinweber K, Bartulos CR, Philipp B, Kroth PG (2015): Biofilm and Capsule Formation of the Diatom Achnathidium minutissimum are affected by a Bacterium. J Phycol 51, 2, 343–355

Wojciechowski F, Groß A, Holder IT, Knörr L, Drescher M, Hartig JS (2015): Pulsed EPR spectroscopy distance measurements of DNA internally labelled with Gd3+-DOTA. Chem Commun 2015, 72, 13850-13853

 Wyss LA, Nilforoushan A, Eichenseher F, Suter U, Blatter N, Marx A, Sturla SJ (2015): Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase. J Am Chem Soc 137, 1, 30-33

Zhao T, Grützke M, Götz KH, Druzhenko T, Huhn T (2015): Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates. Dalton Trans 44, 37, 16475-16485


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Aschenbrenner J, Drum M, Topal H, Wieland M, Marx A (2014): Direct Sensing of 5-Methylcytosine by Polymerase Chain Reaction. Angew Chem Int Ed 53, 31, 8154-8158

Ausländer S, Stücheli P, Rehm C, Ausländer D, Hartig JS, Fussenegger M (2014): A general design strategy for protein-responsive riboswitches in mammalian cells. Nat Methods 11, 11, 1154-1160

Balmer NV, Klima S, Rempel E, Ivanova VN, Kolde R, Weng MK, Meganathan K, Henry M, Sachinidis A, Berthold MR, Hengstler JG, Rahnenführer J, Waldmann T, Leist M (2014): From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol 88, 7, 1451-1468

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Blatter N, Prokup A, Deiters A, Marx A (2014): Modulating the pKa of a tyrosine in KlenTaq DNA polymerase that is crucial for abasic site bypass by in vivo incorporation of a non-canonical amino acid. ChemBioChem 15, 12, 1735-1737

Brockmann A, Strittmatter T, May S, Stemmer K, Marx A, Brunner T (2014): Structure-function relationship of thiazolide-induced apoptosis in colorectal tumor cells. ACS Chemical Biology 9, 7, 1520-1527

Busch H, Stempfle F, Hess S, Grau E, Mecking S (2014): Selective Isomerization-Carbonylation of a Terpene trisubstituted double bond. Green Chem 16, 10, 4541-4545

Bußkamp H, Batroff E, Niederwieser A, Abdel-Rahman OS, Winter RF, Wittmann V, Marx A (2014): Efficient labelling of enzymatically synthesized vinyl-modified DNA by an inverse-electron-demand Diels–Alder reaction. Chem Commun 50, 10827-10829

Bußkamp H, Keller S, Robotta M, Drescher M, Marx A (2014): A new Building Block for DNA Network Formation by Self-Assembly and Polymerase Chain Reaction. Beilstein J Org Chem 10, 1037-1046

Damnjanovic B, Apell H-J (2014): KdpFABC Reconstituted in Escherichia coli Lipid Vesicles: Substrate Dependence of the Transport Rate. Biochemistry 53, 35, 5674−5682

Denger K, Weiss M, Felux A-K, Schneider A, Mayer C, Spiteller D, Huhn T, Cook AM, Schleheck D (2014): Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Nature 507, 114-117

Deutzmann A, Ganz M, Schonenberger F, Vervoorts J, Kappes F, Ferrando-May E (2014): The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. Oncogene, 34, 4270–4277

Devadoss Victor Paul Raj FR, Exner TE (2014): Cα torsion angles as a flexible criterion to extract secrets from a molecular dynamics simulation. J Mol Model 20, 2196

Drexler J, Groth U (2014): Trifluoromethylated Nucleosides: A Building Block Approach to Cytotoxic Adenosine Analogues. Eur J Org Chem 28, 6314-6320

Drum M, Kranaster R, Ewald C, Blasczyk R, Marx A (2014): Variants of a Thermus aquaticus DNA Polymerase with Increased Selectivity for Applications in Allele- and Methylation-Specific Amplification. PLoS ONE 9, 5, e96640

Fischer JMF, Popp O, Gebhard D, Veith S, Fischbach A, Beneke S, Leitenstorfer A, Bergemann J, Scheffner M, Ferrando-May E, Mangerich A, Bürkle A (2014): Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J 281, 16, 3625-3641

Gutierrez Acosta O, Schleheck D, Schink B (2014): Acetone utilization by sulfate-reducing bacteria: draft genome sequence of Desulfococcus biacutus and a proteomic survey of acetone-inducible proteins. BMC Genomics 15, 1, 584

Gutiérrez Acosta OB, Hardt N, Hacker SM, Strittmatter T, Schink B, Marx A (2014): Thiamine pyrophosphate stimulates acetone activation by Desulfococcus biacutus as monitored by a fluorogenic ATP analogue. ACS Chemical Biology 9, 6, 1263-1266

Hacker SM, Hintze C, Marx A, Drescher M (2014): Monitoring enzymatic ATP hydrolysis by EPR spectroscopy. Chem Commun 50, 7262-7264

Hacker SM, Mortensen F, Scheffner M, Marx A (2014): Selective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit. Angew Chem Int Ed 53, 38, 10247-10250

Häfner J, Mayr MI, Möckel MM, Mayer TU (2014): Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nature Communications 5, 4397

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Hoelting L, Leist M, Stoppini L  (2014): Using Pluripotent Stem Cells and Their Progeny as an In Vitro Model to Assess (Developmental) Neurotoxicity. In:  Pfannkuch F, Sauter-Dick L: Predictive Toxicology from Vision to Reality Wiley-VCH.

Holert J, Yücel O, Suvekbala V, Kulić Ž, Möller H, Philipp B (2014): Evidence of distinct pathways for bacterial degradation of the steroid compound cholate suggests the potential for metabolic interactions by interspecies cross-feeding. Environ Microbiol 16, 5, 1424-1440

Juneja P, Horlacher R, Bertrand D, Krause R, Fabrice M, Welte W (2014): An internally modulated, thermostable, pH sensitive Cys-loop receptor from the hydrothermal vent worm Alvinella pompejana. J Biol Chem 289, 21, 15130-15140

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Juneja P, Rao A, Cölfen H, Diederichs K, Welte W (2014): Crystallization and preliminary X-ray analysis of the C-type lectin domain of the spicule matrix protein SM50 from Strongylocentrotus purpuratus. Acta Crystallogr F 70, Pt 2, 260-262

Kniepert A, Groettrup M (2014): The unique functions of tissue-specific proteasomes. Trends Biochem Sci 39, 1, 17-24

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Kubik G, Schmidt MJ, Penner JE, Summerer D (2014): Programmable and highly resolved in vitro detection of genomic 5-methylcytosine by TALEs. Angew Chem Int Ed 53, 23, 6002-6006

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Pott M, Schmidt MJ, Summerer D (2014): Evolved Sequence Contexts for Highly Efficient Amber Suppression with Noncanonical Amino Acids. ACS Chemical Biology 9, 12, 2815-2822

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Rao A, Berg JK, Kellermeier M, Gebauer D (2014): Sweet on biomineralization: effects of carbohydrates on the early stages of calcium carbonate crystallization. Eur J Mineral 26, 4, 537-552

Rehm C, Holder IT, Groß A, Wojciechowski F, Urban M, Sinn M, Drescher M, Hartig JS (2014): A bacterial DNA quadruplex with exceptional K+ selectivity and unique structural polymorphism. Chem Sci 5, 7, 2809-2818

Robotta M, Gerding HR, Vogel A, Hauser K, Schildknecht S, Karreman C, Leist M, Subramaniam V, Drescher M (2014): Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation. ChemBioChem 15, 17, 2499-2502

Roesle P, Stempfle F, Hess S, Zimmerer J, Bártulos CR, Lepetit B, Eckert A, Kroth PG, Mecking S (2014): Synthetic Polyester from Algae Oil. Angew Chem Int Ed 53, 26, 6800-6804

Schmidt MJ, Borbas J, Drescher M, Summerer D (2014): A genetically encoded spin label for EPR distance measurements. J Am Chem Soc 136, 4, 1238-1241

Schmidt MJ, Summerer D (2014): Genetic code expansion as a tool to study regulatory processes of transcription. Frontiers in Chemistry 2, 7, 1-11

Schmidt MJ, Weber A, Pott M, Welte W, Summerer D (2014): Structural basis of furan-amino acid recognition by a polyspecific aminoacyl-tRNA-synthetase for its genetic encoding in human cells. ChemBioChem 15, 12, 1755-1760

Schmidt MS, Leitner K, Welter M, Wurmthaler LA, Ringwald M (2014): Carbohydrate-based Cu(I) stabilizing ligands and their use in the synthesis of carbohydrate–ferrocene conjugates. Carbohyd Res 387, 42-45

Schneider T, Schneider D, Rösner D, Malhotra S, Mortensen F, Mayer TU, Scheffner M, Marx A (2014): Dissecting ubiquitin signaling by linkage-defined and protease resistant ubiquitin chains. Angew Chem Int Ed 53, 47, 12925-12929

Seto J, Picker A, Chen Y, Rao A, Evans JS, Cölfen H (2014): Nacre Protein Sequence Compartmentalizes Mineral Polymorphs in Solution. Cryst Growth Des 14, 4, 1501-1505

Seto J, Rao A, Cölfen H  (2014): Hierarchically Nanostructured Biological Materials. In:  Zhang Q, Wei F: Advanced Hierarchical Nanostructured Materials, 35-70.

Sommer R, Exner TE, Titz A (2014): A Biophysical Study with Carbohydrate Derivatives Explains the Molecular Basis of Monosaccharide Selectivity of the Pseudomonas aeruginosa Lectin LecB. PLoS ONE 9, 11, e112822

Späte A-K, Bußkamp H, Niederwieser A, Schart VF, Marx A, Wittmann V (2014): Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter. Bioconjugate Chem 25, 1, 147-154

Späte A-K, Schart VF, Häfner J, Niederwieser A, Mayer TU, Wittmann V (2014): Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions. Beilstein J Org Chem 10, 2235-2242

Späte A-K, Schart VF, Schöllkopf S, Niederwieser A, Wittmann V (2014): Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering. Chem Eur J 20, 50, 16502-16508

Spinnenhirn V, Farhan H, Basler M, Aichem A, Canaan A, Groettrup M (2014): The Ubiquitin-like Modifier FAT10 Decorates Autophagy-Targeted Salmonella and Contributes to Salmonella Resistance in Mice. J Cell Sci 127, 22, 4883-4893

Strittmatter T, Brockmann A, Pott M, Hantusch A, Brunner T, Marx A (2014): Expanding the Scope of Human DNA Polymerase λ and β Inhibitors. ACS Chemical Biology 9, 1, 282-290

Wang Y, Rösner D, Grzywa M, Marx A (2014): Chain terminating and clickable NAD+ analogues for labeling target proteins of ADP-ribosyltransferases. Angew Chem Int Ed 53, 31, 8159-8162

Weng MK, Natarajan K, Scholz D, Ivanova VN, Sachinidis A, Hengstler JG, Waldmann T, Leist M (2014): Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain. PLoS ONE 9, 7, e102035

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Azarkh M, Singh V, Okle O, Seemann I, Dietrich D, Hartig JS, Drescher M (2013): Site-directed spin-labeling of nucleotides and the use of in-cell EPR to determine long-range distances in a biologically relevant environment. Nat Protoc 8, 1, 131-147

Bergen K, Betz K, Welte W, Diederichs K, Marx A (2013): Structures of KOD and 9°N DNA polymerases complexed with primer template duplex. ChemBioChem 14, 9, 1058-1062

Betz K, Malyshev DA, Lavergne T, Welte W, Diederichs K, Romesberg FE, Marx A (2013): Structural insights into DNA replication without hydrogen bonds. J Am Chem Soc 135, 49, 18637-18643

Blatter N, Bergen K, Nolte O, Welte W, Diederichs K, Mayer J, Wieland M, Marx A (2013): Structure and function of an RNA-reading thermostable DNA polymerase. Angew Chem Int Ed 52, 45, 11935-11939

Felux A-K, Denger K, Weiss M, Cook AM, Schleheck D (2013): Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed by spontaneous desulfination to yield acetaldehyde, and finally acetate for growth. J Bacteriol 195, 12, 2921-2930

Gisin J, Schneider A, Nägele B, Borisova M, Mayer C (2013): A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nat Chem Biol (AOP) 9, 491-493

Gutiérrez Acosta OB, Hardt N, Schink B (2013): Carbonylation as a Key Reaction in Anaerobic Acetone Activation by Desulfococcus biacutus. Appl Environ Microbiol 79, 20, 6228-6235

Hacker SM, Hardt N, Buntru A, Pagliarini D, Möckel M, Mayer TU, Scheffner M, Hauck CR, Marx A (2013): Fingerprinting Differential Active Site Constraints of ATPases. Chem Sci 4, 4, 1588-1596

Hacker SM, Pagliarini D, Tischer T, Hardt N, Schneider D, Mex M, Mayer TU, Scheffner M, Marx A (2013): Novel Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real-Time. Angew Chem Int Ed 52, 45, 11916-11919

Hardt N, Hacker SM, Marx A (2013): Synthesis and Fluorescence Characteristics of ATP-based FRET probes. Org Biomol Chem 11, 48, 8298-2305

Hauck D, Joachim I, Frommeyer B, Varrot A, Philipp B, Möller HM, Imberty A, Exner T, Titz A (2013): Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes. ACS Chemical Biology 8, 8, 1775-1784

Hoelting L, Scheinhardt B, Bondarenko O, Schildknecht S, Kapitza M, Tanavde V, Tan B, Lee QY, Mecking S, Leist M, Kadereit S (2013): A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles. Arch Toxicol 87, 4, 721-733

Holder IT, Drescher M, Hartig JS (2013): Structural Characterization of Quadruplex DNA with in-cell EPR approaches. Bioorgan Med Chem 21, 20, 6156-6161

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Horn M, Berthold MR (2013): Learning Precise Local Boundaries in Images from Human Tracings. In: A P: Image Analysis and Processing - ICIAP 2013: Lecture Notes in Computer Science Springer, 131-140.

Ivanova VN, Berthold MR (2013): Diversity-Driven Widening. Advances in Intelligent Data Analysis XII: 12th International Symposium IDA: Proceedings: Lecture Notes in Computer Science 8207, 223-236

Jüngst C, Klein M, Zumbusch A (2013): Long-term live cell microscopy studies of lipid droplet fusion dynamics in adipocytes. J Lipid Res 54, 12, 3419-3429

Kalim KW, Groettrup M (2013): Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. Mol Immunol 53, 3, 274-282

Kang JH, Schartl M, Walter RB, Meyer A (2013): Comprehensive phylogenetic analysis of all species of swordtails and platies (Pisces: Genus Xiphophorus) uncovers a hybrid origin of a swordtail fish, Xiphophorus monticolus, and demonstrates that the sexually selected sword originated in the ancestral lineage of the genus, but was lost again secondarily. BMC Evol Biol 13, 25, 1-19

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Kulić Ž, Fritz G, Möller H (2013): 1H, 13C, and 15N resonance assignments of the second immunoglobulin domain of neurolin from Carassius auratus. Biomol NMR Assign 7, 1, 65-67

Martello R, Mangerich A, Sass S, Dedon PC, Bürkle A (2013): Quantification of Cellular Poly(ADP-ribosyl)ation by Stable Isotope Dilution Mass Spectrometry Reveals Tissue- and Drug-Dependent Stress Response Dynamics. ACS Chemical Biology 8, 7, 1567-1575

Miller RE, Sommer R, Fan H, Snieckus V, Groth U (2013): Combined Directed Metalation - Suzuki-Miyaura Cross Coupling Strategies. Synthesis of Isomeric Chromenopyridinones and Related Annulated Analogues. ChemInform 44, 18

Min W, Bruhn C, Grigaravicius P, Zhou Z-W, Li F, Krüger A, Siddeek B, Greulich K-O, Popp O, Meisezahl C, Calkhoven CF, Bürkle A, Xu X, Wang Z-Q (2013): Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nature Communications 4, 2993

Muller N, Moreno-Villanueva M, Fischbach A, Kienhofer J, Martello R, Dedon PC, Ullrich V, Burkle A, Mangerich A (2013): An automated Fpg-based FADU method for the detection of oxidative DNA lesions and screening of antioxidants. Toxicology 310, 15-21

Nathan JA, Spinnenhirn V, Schmidtke G, Basler M, Groettrup M, Goldberg AL (2013): Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins. Cell 152, 5, 1184-1194

Niederwieser A, Späte A-K, Nguyen LD, Jüngst C, Reutter W, Wittmann V (2013): Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry. Angew Chem Int Ed 52, 15, 4265-4268

Obeid S, Bußkamp H, Welte W, Diederichs K, Marx A (2013): Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. J Am Chem Soc 135, 42, 15667-15669

Offen N / Kang JH, Meyer A, Begemann G (2013): Retinoic Acid Is Involved in the Metamorphosis of the Anal Fin into an Intromittent Organ, the Gonopodium, in the Green Swordtail (Xiphophorus hellerii). PLoS ONE 8, 10, e77580

Popp O, Veith S, Fahrer J, Bohr VA, Bürkle A, Mangerich A (2013): Site-Specific Noncovalent Interaction of the Biopolymer Poly(ADPribose) with the Werner Syndrome Protein Regulates Protein Functions. ACS Chemical Biology 8, 1, 179-188

Rao A, Seto J, Berg JK, Kreft SG, Scheffner M, Cölfen H (2013): Roles of larval sea urchin spicule SM50 domains in organic matrix self-assembly and calcium carbonate mineralization. J Struct Biol 183, 2, 205-215

Rosazza C, Buntz A, Riess T, Woll D, Zumbusch A, Rols MP (2013): Intracellular tracking of single-plasmid DNA particles after delivery by electroporation. Mol Ther 21, 12, 2217-2226

Saragliadis A, Krajewski SS, Rehm C, Narberhaus F, Hartig JS (2013): Thermozymes: Synthetic RNA thermometers based on ribozyme activity. RNA Biol 10, 6, 1010-1016

Scheinhardt B, Trzaskowski J, Baier MC, Stempfle B, Oppermann A, Wöll D, Mecking S (2013): Anisotropic Polyethylene Nanocrystals Labeled with a Single Fluorescent Dye Molecule: Toward Monitoring of Nanoparticle Orientation. Macromolecules 46, 19, 7902-7910

Schildknecht S, Weber A, Gerding H, Pape R, Robotta M, Drescher M, Marquardt A, Daiber A, Ferger B, Leist M (2013): The NOX1/4 Inhibitor GKT136901 As Selective and Direct Scavenger of Peroxynitrite. Current Med Chem 21, 3, 365-376

Schmidt A, Müller N, Schink B, Schleheck D (2013): A proteomic view at the biochemistry of syntrophic butyrate oxidation in Syntrophomonas wolfei. PLoS ONE 8, 2, 1-17

Schmidt MJ, Summerer D (2013): Red-Light-Controlled Protein-RNA Crosslinking with a Genetically Encoded Furan. Angew Chem Int Ed 52, 17, 4690-4693

Schneider D / Schneider T / Rösner D, Scheffner M, Marx A (2013): Improving bioorthogonal protein ubiquitylation by click reaction. Bioorgan Med Chem 21, 12, 3430-3435

Strittmatter T, Aschenbrenner J, Hardt N, Marx A (2013): Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides. Arkivoc 2, 46-59

Weiss M, Kesberg AI, LaButti KM, Pitluck S, Bruce D, Hauser L, Copeland A, Woyke T, Lowry S, Lucas S, Land ML, Goodwin L, Kjelleberg S, Cook AM, Buhmann M, Thomas T, Schleheck D (2013): Permanent draft genome sequence of Comamonas testosteroni KF-1. Standards in Genomic Sciences 8, 2, 239-254

Windler M, Gruber A, Kroth PG (2013): Purification of Benthic Diatoms from Associated Bacteria using the Antibiotic Imipenem. J Endocytobiosis and Cell Research 22, 62-65.


Aichem A, Kalveram B, Spinnenhirn V, Kluge K, Catone N, Johansen T, Groettrup M (2012): The Proteomic Analysis of Endogenous FAT10 Substrates Identifies p62/SQSTM1 as a Substrate of FAT10ylation. J Cell Sci 125, 19, 4576-4585

Akbar Z, Ivanova VN, Berthold MR  (2012): Parallel Data Mining Revisited. Better, Not Faster. In:  Hollmen J KF, Tucker A: Intelligent Engineering Systems (INES), IEEE 16th International Conference on IEEE, 23-34.

Azarkh M, Singh V, Okle O, Dietrich D, Hartig JS, Drescher M (2012): Intracellular conformations of human telomeric quadruplexes studied by electron paramagnetic resonance spectroscopy. ChemPhysChem 13, 6, 1444-1447

Baccaro A, Steck A-L, Marx A (2012): Barcode-modifizierte Nukleotide. Angew Chem Int Ed 51, 1, 254-257 / Angew Chem 124, 1, 260-263

Beckmann HSG, Niederwieser A, Wiessler M, Wittmann V (2012): Preparation of Carbohydrate Arrays by Using Diels–Alder Reactions with Inverse Electron Demand. Chem Eur J 18, 21, 6548–6554

Bergen K / Steck A-L, Strütt S, Baccaro A, Welte W, Diederichs K, Marx A (2012): Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7-Deazapurine Nucleoside Triphosphates. J Am Chem Soc 134, 29, 11840-11843

Betz K, Malyshev DA, Lavergne T, Welte W, Diederichs K, Dwyer TJ, Ordoukhanian P, Romesberg FE, Marx A (2012): KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry. Nat Chem Biol 8, 612-614

Buntru A, Roth A, Nyffenegger-Jann NJ, Hauck CR (2012): HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens. Arch Biochem Biophys 524, 1, 77-83

Eger S, Scheffner M, Marx A, Rubini M (2012): Formation of Ubiquitin Dimers via Azide–Alkyne Click Reaction. Meth Mol Biol 832, 5, 589-596

Hacker SM, Mex M, Marx A (2012): Synthesis and Stability of Phosphate Modified ATP Analogues. J Org Chem 77, 22, 10450-10454

Halder K, Benzler M, Hartig JS (2012): Reporter assays for studying quadruplex nucleic acids. Methods 57, 1, 115-121

Holzberger B, Obeid S, Welte W, Diederichs K, Marx A (2012): Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins. Chem Sci 3, 10, 2924-2931

Holzberger B, Pszolla MG, Marx A, Möller HM (2012): KlenTaq DNA polymerase adopts unique recognition states when encountering matched, mismatched, and abasic template sites - An NMR study. ChemBioChem 13, 5, 635-639

Holzberger B / Strohmeier J, Siegmund V, Diederichsen U, Marx A (2012): Enzymatic synthesis of 8-vinyl- and 8-styryl-2’-deoxyguanosine modified DNA – novel fluorescent molecular probes. Bioorg Med Chem Lett 22, 9, 3136-3139

Huber EM, Basler M, Schwab R, Heinemeyer W, Kirk CJ, Groettrup M, Groll M, (EMH MaRce (2012): Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity. Cell 148, 4, 727-738

Immel TA, Grützke M, Batroff E, Groth U, Huhn T (2012): Cytotoxic Dinuclear Titanium-Salan Complexes: Structural and Biological Characterization. J Inorg Biochem 106, 1, 68-75

Immel TA, Grützke M, Späte A-K, Groth U, Öhlschläger P, Huhn T (2012): Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy. Chem Commun 48, 46, 5790-5792

Kalim KW, Basler M, Kirk CJ, Groettrup M (2012): Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation. J Immunol 189, 8, 4182-4193

Kopp K / Buntru A, Pils S, Zimmermann T, Frank R, Zumbusch A, Hauck CR (2012): Grb14 Is a Negative Regulator of CEACAM3-mediated Phagocytosis of Pathogenic Bacteria. J Biol Chem 287, 46, 39158-39170

Korb O, ten Brink T, Devadoss Victor Paul Raj FR, Keil M, Exner TE (2012): Are predefined decoy sets of ligand poses able to quantify scoring function accuracy? J Comput Aided Mol Des 26, 2, 185-197

Kuegler PB, Baumann BA, Zimmer B, Keller S, Marx A, Kadereit S, Leist M (2012): GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells. Glia 60, 2, 218-228

Maiti M, Siegmund V, Abramov M, Lescrinier E, Rosemeyer H, Froeyen M, Ramaswamy A, Ceulemans A, Marx A, Herdewijn P (2012): Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acid (dXNA): An Orthogonal Nucleic Acid Candidate. Chem Eur J 18, 3, 869-879

Mangerich A / Veith S, Popp O, Fahrer J, Martello R, Bohr VA, Bürkle A (2012): Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry. Mech Ageing Dev 133, 8, 575-579

Obeid S, Bußkamp H, Welte W, Diederichs K, Marx A (2012): Interactions of Non-Polar and “Click-able” Nucleotides in the Confines of a DNA Polymerase. Chem Commun 48, 67, 8320-8322

Obeid S, Welte W, Diederichs K, Marx A (2012): Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family A DNA polymerase. J Biol Chem 287, 17, 14099-14108

Paar M / Jüngst C, Steiner NA, Magnes C, Sinner F, Kolb D, Lass A, Zimmermann R, Zumbusch A, Kohlwein SD, Wolinski H, equally) MaCc (2012): Remodeling of lipid droplets during lipolysis and growth in adipocytes. J Biol Chem 287, 14, 11164-11173

Pöltl D, Schildknecht S, Karreman C, Leist M (2012): Uncoupling of ATP-depetion and cell death in human dopaminergic neurons. Neurotoxicology 33, 4, 769-779

Robotta M, Hintze C, Schildknecht S, Zijlstra N, Jüngst C, Karreman C, Huber M, Leist M, Subramaniam V, Drescher M (2012): Locally Resolved Membrane Binding Affinity of the N-Terminus of α-Synuclein. Biochemistry 51, 19, 3960-3962

Santner T, Siegmund V, Marx A, Micura R (2012): The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates. Bioorgan Med Chem 20, 7, 2416-2418

Schmidt MJ, Summerer D (2012): A need for speed: genetic encoding of rapid cycloaddition chemistries for protein labelling in living cells. ChemBioChem 13, 11, 1553-1557

Schütze F, Stempfle B, Jüngst C, Wöll D, Zumbusch A, Mecking S (2012): Fluorescent conjugated block copolymer nanoparticles by controlled mixing. Chem Commun 48, 15, 2104-2106

Siegmund V, Santner T, Micura R, Marx A (2012): Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2′-modified nucleotides. Chem Commun 48, 79, 9870-9872

Singh V, Azarkh M, Drescher M, Hartig JS (2012): Conformations of individual quadruplex units studied in the context of extended human telomeric DNA. Chem Commun 48, 66, 8258-8260

Strobelt H, Bertini E, Braun J, Deussen O, Groth U, Mayer TU, Merhof D (2012): HiTSEE KNIME: a visualization tool for hit selection and analysis in high-throughput screening experiments for the KNIME platform. BMC Bioinformatics 13, (Suppl 8) 54, 1-13

Stuerner E, Kuraku S, Hochstrasser M, Kreft SG (2012): Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene. PLoS ONE 7, 10, e45194

Voges M, Bachmann V, Hauck CR, Kopp K, Naujoks J (2012): Extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens. PLoS ONE 7, 6, e39908

Weiss M, Denger K, Huhn T, Schleheck D (2012): Two enzymes of a complete degradation pathway for linear alkylbenzenesulfonate (LAS) surfactants: 4-sulfoacetophenone Baeyer-Villiger monooxygenase and 4-sulfophenylacetate esterase in Comamonas testosteroni KF-1. Appl Environ Microbiol 78, 23, 8254-8263

Weng M, Zimmer B, Pöltl D, Broeg MP, Ivanova V, Gaspasr J, Sachinidis A, Wüllner U, Waldmann T, Leist M (2012): Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment. PLoS ONE 7, 5, e36708


Azarkh M / Okle O, Eyring P, Dietrich D, Drescher M (2011): Evaluation of spin labels for in-cell EPR by analysis of nitroxide reduction in cell extract of Xenopus laevis oocytes. J Magn Reson 212, 2, 450-454

Azarkh M, Okle O, Singh V, Seemann I, Hartig JS, Dietrich D, Drescher M (2011): Long-Range Distance Determination in a DNA Model System inside Xenopus laevis Oocytes by In-Cell Spin-Label EPR. ChemBioChem 12, 13, 1992-1995

Benz A, Singh V, Mayer TU, Hartig JS (2011): Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening. ChemBioChem 12, 9, 1422-1426

Bertini E, Strobelt H, Bertini E, Braun J, Deussen O, Groth U, Mayer TU, Merhof D (2011): HiTSEE: A Visualization Tool for Hit Selection and Analysis in High-Throughput Screening Experiments. 1st IEEE Symposium on Biological Data Visualization (IEEE BioVis) 13, Suppl 8, 95-102.

Bruckner C, Rehm C, Grossart H-P, Kroth PG (2011): Growth and Release of extracellular organic Compounds by benthic Diatoms depend on Interactions with Bacteria. Environ Microbiol 13, 4, 1052-1063

Buntru A / Kopp K, Voges M, Frank R, Bachmann V, Hauck CR (2011): Phosphatidylinositol-3´Kinase activity is critical for initiating the oxidative burst and bacterial destruction during ceacam3-mediated phagocytosis. J Biol Chem 286, 11, 9555-9566

Cirri E, Katz A, Mishra NK, Belogus T, Lifshitz Y, Garty H, Karlish SJD, Apell H-J (2011): Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions. Biochemistry 50, 18, 3736-3748

Eger S, Castrec B, Hübscher U, Scheffner M, Rubini M, Marx A (2011): Generation of a Mono-ubiquitinated PCNA Mimic by Click Chemistry. ChemBioChem 12, 18, 2807-2812

Fowler CI, Muchemu CM, Miller RE, Phan L, O’Neill C, Jessop PG, Cunningham MF (2011): Emulsion Polymerization of Styrene and Methyl Methacrylate Using Cationic Switchable Surfactants. Macromolecules 44, 8, 2501-2509

Gieseking S, Bergen K, Pasquale FD, Diederichs K, Welte W, Marx A (2011): Human DNA Polymerase β Mutations Allowing Efficient Abasic Site Bypass. J Biol Chem 286, 5, 4011-4020

Halder K, Largy E, Benzler M, Teulade-Fichou M-P, Hartig JS (2011): Efficient Suppression of Gene Expression by Targeting 5'-UTR-Based RNA Quadruplexes with Bisquinolinium Compounds. ChemBioChem 12, 11, 1663-1668

Hamecher J, Riess T, Bertini E, Kozak K, Kastl J, Mayer TU, Merhof D (2011): A Versatile Framework for the Analysis of High-Throughput Screening Data. 8th Int Workshop on Computational Systems Biology (WCSB), 57-60.

Hoffmann C, Berking A, Agerer F, Buntru A, Neske F, Chhatwal GS, Ohlsen K, Hauck CR (2011): Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens. J Cell Sci 123, Pt 24, 4280-4291

Horn M, Berthold MR (2011): Towards active segmentation of cell images. Biomedical Imaging: From Nano to Macro. 2011 IEEE International Symposium, 177-181

Hovers J, Potschies M, Polidori A, Pucci B, Raynal S, Bonneté F, Serrano-Vega MJ, Tate CG, Picot D, Pierre Y, Popot J-L, Nehmé R, Bidet M, Mus-Veteau I, Bußkamp H, Jung K-H, Marx A, Timmins PA, Welte W (2011): A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization. Mol Membr Biol 28, 3, 170-180

Huber J, Scheinhardt B, Geldhauser T, Boneberg J, Mecking S (2011): Polymerization Catalyst Laser-Interference Patterning. Angew Chem Int Ed 50,41, 9665-9667 / Angew Chem 123, 41, 9839-9841

Immel TA, Groth U, Huhn T, Öhlschläger P (2011): Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice. PLoS ONE 6, 3, e17869

Jüngst C, Winterhalder MJ, Zumbusch A (2011): Fast and long term lipid droplet tracking with CARS microscopy. J Biophotonics 4, 6, 435-441

Mishra NK, Peleg Y, Cirri E, Belogus T, Lifshitz Y, Voelker DR, Apell H-J, Garty H, Karlish SJD (2011): FXYD proteins stabilize Na, K-ARPase: amplification od specific phosphatidylserine-protein interactions. J Biol Chem 286, 11, 9699-9712

Obeid S, Schnur A, Gloeckner C, Blatter N, Welte W, Diederichs K, Marx A (2011): Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity. ChemBioChem 12, 10, 1574-1580

Reichmann B, Drexler M, Weibert B, Szesni N, Strittmatter T, Fischer H (2011): Amino-Substituted Butatrienes: η1 Ligands Formed by an Unusual Reaction. Organometallics 30, 5, 1215-1223

Rieß T, Dietz C, Horn M, Deussen O, Waldmann T, Leist M, Merhof D  (2011): Automated quantification of histone relocation in cell nuclei. In:  Tavares JMRS, Natal Jorge RM: VipIMAGE2011 - 3rd ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing Taylor & Francis, 423-428.

Robotta M, Braun P, van Rooijen B, Subramaniam V, Huber M, Drescher M (2011): Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein. ChemPhysChem 12, 2, 267-269

Schildknecht S, Pape R, Müller N, Robotta M, Marquardt A, Bürkle A, Drescher M, Leist M (2011): Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. J Biol Chem 286, 7, 4991-5002

Schleheck D, Weiss M, Pitluck S, Bruce D, Land ML, Han S, Saunders E, Tapia R, Detter C, Brettin T, Han J, Woyke T, Goodwin L, Pennacchio L, Nolan M, Cook AM, Kjelleberg S, Thomas T (2011): Complete genome sequence of Parvibaculum lavamentivorans type strain (DS-1(T)). Standards in Genomic Sciences 5, 3, 298-310

Scholz D, Pöltl D, Genewsky A, Weng M, Waldmann T, Schildknecht S, Leist M (2011): Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem 119, 5, 957-971

Scior A / Preissler S, Koch M, Deuerling E (2011): Directed PCR-free engineering of highly repetitive DNA sequences. BMC Biotechnol 11, 87, 1-9

Seemann I, Hartig JS (2011): Artificial Ribozyme-Based Regulators of Gene Expression. Synlett 11, 1486-1494

Seemann I, Singh V, Azarkh M, Drescher M, Hartig JS (2011): Small-Molecule-Triggered Manipulation of DNA Three-Way Junctions. J Am Chem Soc 133, 13, 4706-4709

Sidler D, Brockmann A, Mueller J, Nachbur U, Corazza N, Renzulli P, Hemphill A, Brunner T (2011): Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. Oncogene 31, 37, 4095–4106

Siegmund V, Santner T, Micura R, Marx A (2011): Enzymatic synthesis of 2’-methylseleno-modified RNA. Chem Sci 2, 11, 2224-2231

Singh V, Benz A, Hartig JS (2011): G-quadruplexes stabilized by 8-oxo-2´-deoxyguanosine. Chem Eur J 17, 39, 10838-10843

Strittmatter T, Bareth B, Immel TA, Huhn T, Mayer TU, Marx A (2011): Small Molecule Inhibitors of Human DNA Polymerase λ. ACS Chemical Biology 6, 4, 314-319

Vlad C, Lindner K, Karreman C, Schildknecht S, Leist M, Tomczyk N, Rontree J, Langridge J, Danzer K, Ciossek T, Petre A, Gross ML, Hengerer B, Przybylski M (2011): Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry. ChemBioChem 12, 18, 2740-2744

Zimmer B, Schildknecht S, Kügler PB, Tanavde V, Kadereit S, Leist M (2011): Sensitivity of dopaninergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicol Sci 121, 2, 357-367


Beneke S, Scherr A-L, Ponath V, Popp O, Bürkle A (2010): Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span. Mech Ageing Dev 131, 5, 366-369

Betz K, Streckenbach F, Schnur A, Exner T, Welte W, Diederichs K, Marx A (2010): Structures of DNA polymerases caught processing size-augmented nucleotide probes. Angew Chem Int Ed 49, 30, 5181-5184

Domingo-Köhler S, Weber A, Howard SP, Welte W, Drescher M (2010): The proline-rich domain of TonB possesses an extended polyproline II-like conformation of sufficient length to span the periplasm of Gram-negative bacteria. Protein Sci 19, 4, 625-630

Dragusanu M, Petre B-A, Slamnoiu S, Vlad C, Tu T, Przybylski M (2010): On-Line Bioaffinity-Electrospray Mass Spectrometry for Simultaneous Detection, Identification, and Quantification of Protein–Ligand Interactions. J Am Soc Mass Spectr 21, 10, 1643-1648

Eger S, Immel TA, Claffey J, Müller-Bunz H, Tacke M, Groth U, Huhn T (2010): Titanocene Difluorides with Improved Cytotoxic Activity. Inorg Chem 49, 4, 1292-1294

Eger S, Scheffner M, Marx A, Rubini M (2010): Synthesis of defined ubiquitin dimers. J Am Chem Soc 132, 46, 16337-16339

Eichmann C / Preissler S, Riek R, Deuerling E (2010): Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy. P Natl Acad Sci USA 107, 20, 9111-9116

Erhardt M, Adamska I, Franco OL (2010): Plant nuclear proteomics-inside the cell maestro. FEBS J 277, 16, 3295-3307

Fahrer J, Popp O, Malanga M, Beneke S, Markovitz DM, Ferrando-May E, Bürkle A, Kappes F (2010): High affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. Biochemistry 49, 33, 7119-7130

Fiaux J / Horst J, Scior A, Preissler S, Koplin A, Bukau B, Deuerling E (2010): Structural analysis of the ribosome-associated complex (RAC) reveals an unusual Hsp70/Hsp40 interaction. J Biol Chem 285, 5, 3227-3234

Fischer GM, Jüngst C, Isomäki-Krondahl M, Gauss D, Möller H, Daltrozzo E, Zumbusch A (2010): Asymmetric PPCys: Strongly fluorescing NIR labels. Chem Commun 46, 29, 5289-5291

Holzberger B, Marx A (2010): Replacing 32 Proline Residues by a Noncanonical Amino Acid Results in a Highly Active DNA Polymerase. J Am Chem Soc 132, 44, 15708-15713

Holzberger B, Rubini M, Möller HM, Marx A (2010): A Highly Active DNA Polymerase with a Fluorous Core. Angew Chem Int Ed 49, 7, 1324-1327 / Angew Chem 122, 7, 1346-1349

Immel TA, Groth U, Huhn T (2010): Cytotoxic Titanium Salan Complexes: Surprising Interaction of Salan and Alkoxy Ligands. Chem Eur J 16, 9, 2775-2789

Immel TA, Martin JT, Dürr CJ, Groth U, Huhn T (2010): Dimethyl titanocene Y: A valuable precursor for libraries of cytotoxic titanocene derivatives. J Inorg Biochem 104, 8, 863-867

Kesenheimer C, Kalogerakis A, Meißner A, Groth U (2010): The Cobalt Way to Angucyclinones: Asymmetric Total Synthesis of the Antibiotics (+)-Rubiginone B2, (-)-Tetrangomycin, and (-)-8-O-Methyltetrangomycin. Chem Eur J 16, 29, 8805-8821

Koplin A, Preissler S, Ilina Y, Koch M, Scior A, Erhardt M, Deuerling E (2010): A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes. J Cell Biol 189, 1, 57-68

Kopylova NA, Grygorenkob OO, Komarov IV, Groth U (2010): Synthesis of enantiopure (R,R)- and (S,S)-cis-2,3-propanoprolines. Tetrahedron-Asymmetr 21, 23, 2868-2871

Kranaster R, Drum M, Engel N, Weidmann M, Hufert FT, Marx A (2010): One-step RNA pathogen detection with reverse transcriptase activity of a mutated thermostable Thermus aquaticus DNA polymerase. Biotechnol J 5, 2, 224-231

Kuegler PB, Zimmer B, Waldmann T, Baudis B, Ilmjärv S, Hescheler J, Gaughwin P, Brundin P, Mundy W, Bal-Price AK, Schrattenholz A, Krause K-H, van Thriel C, Rao MS, Kadereit S, Leist M (2010): Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. Altex-Altern Tierexp 27, 1, 17-42

Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno-Villanueva M, Bruns OT, Bürkle A (2010): Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1. Mech Ageing Dev 131, 6, 389-404

Mayer J, Huhn T, Habeck M, Denger K, Hollemeyer K, Cook AM (2010): 2,3-Dihydroxypropane-1-sulfonate degraded by Cupriavidus pinatubonensis JMP134: purification of dihydroxypropanesulfonate 3-dehydrogenase. Microbiology 156, Pt 5, 1556-1564

Meißner A, Groth U (2010): Intramolecular Cobalt-Catalyzed [2+2+2] Cycloaddition of O-Protected Diyne-Cyanohydrins. Synlett 7, 1051-1054

Miller RE, Rantanen T, Ogilvie KA, Groth U, Snieckus V (2010): Combined Directed ortho Metalation-Halogen Dance (HD) Synthetic Strategies. HD-Anionic ortho Fries Rearrangement and Double HD Sequences. Org Lett 12, 10, 2198-2201

Obeid S, Baccaro A, Welte W, Diederichs K, Marx A (2010): Structural basis for the synthesis of nucleobase modified DNA polymerase. P Natl Acad Sci USA 107, 50, 21327-21331

Obeid S / Blatter N, Kranaster R, Schnur A, Diederichs K, Welte W, Marx A (2010): Replication through an abasic DNA lesion: structural basis for adenine selectivity. EMBO J 29, 10, 1738-1747

Rohmer K, Keiper O, Mannuthodikayil J, Wittmann V (2010): Preparation of Thioacid-Containing Amino Acids and Peptides and Their Application in Ligations Reactions. Peptides: Tales of Peptides (Proc of the 31st European Peptide Symposium), 218-219.

Voges M, Bachmann V, Kammerer R, Gophna U, Hauck CR (2010): CEACAM1 recognition by bacterial pathogens is species-specific. BMC Microbiol 10, 117, 1-11

Wieland M, Berschneider B, Erlacher MD, Hartig JS (2010): Aptazyme-Mediated Regulation of 16S Ribosomal RNA. Chem Biol 17, 3, 236-242

Wieland M, Benz A, Haar J, Halder K, Hartig JS (2010): Small molecule-triggered assembly of DNA nanoarchitectures. Chem Commun 46, 11, 1866-1868

Zimmer B, Kügler PB, Baudis B, Genewsky A, Tanavde V, Koh W, Tan B, Waldmann T, Kadereit S, Leist M (2010): Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death Differ 18, 3, 383-395


Berschneider B, Wieland M, Rubini M, Hartig JS (2009): Small-Molecule-Dependent Regulation of Transfer RNA in Bacteria. Angew Chem Int Ed 2009, 48, 7564-7567

Buntru A, Hauck CR (2009): Visualisierung von Bakterien-induzierten Signalen. BIOspektrum 2009, 6, 628-631.

Buntru A, Zimmermann T, Hauck CR (2009): Fluorescence resonance energy transfer (FRET)-based subcellular visualization of pathogen-induced host receptor signaling. BMC Biol 2009, 7, 81

Catarinella M, Grüner T, Strittmatter T, Marx A, Mayer TU (2009): BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed 2009, 48, 9072-9076 / Angew Chem 2009, 121, 9236-9240

Denger K, Mayer J, Buhmann M, Weinitschke S, Smits THM, Cook AM (2009): Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase. J Bacteriol 2009, 191, 5648-5656

Groth U, Iaroshenko VO, Wang Y, Wesch T (2009): Facile Synthesis of Fluorinated Pyrrolo[2,3-b]pyridines. Synlett 2009, 456-460

Groth U, Jung M, Lang S, Schuppler T (2009): Chromium(II)-catalyzed diastereoselective pinacol type cross coupling: studies of substrate-controlled effects. Tetrahedron Lett 2009, 50, 152-154

Habeck M, Cirri E, Katz A, Karlish SJ, Apell HJ (2009): Investigation of Electrogenic Partial Reactions in Detergent-Solubilized Na,K-ATPase. Biochemistry 2009, 48, 9147–9155

Halder K, Wieland M, Hartig JS (2009): Predictable suppression of gene expression by 50-UTR-based RNA quadruplexes. Nucleic Acids Res 2009, 37, 6811-6817

Holzberger B, Marx A (2009): Enzymatic synthesis of perfluoroalkylated DNA. Bioorgan Med Chem 2009, 17, 3653–3658

Immel TA, Debiak M, Groth U, Bürkle A, Huhn T (2009): Highly Selective Apoptotic Cell Death Induced by Halo-Salane Titanium Complexes. ChemMedChem 2009, 738-741

Joachimi A, Benz A, Hartig JS (2009): A comparison of DNA and RNA quadruplex structures and stabilities. Bioorgan Med Chem 2009, 17, 6811-6815

Lang S, Groth U (2009): Total Syntheses of Cytotoxic, Naturally Occurring Kalasinamide, Geovanine, and Marcanine A. Angew Chem Int Ed 2009, 48, 911–913 / Angew Chem 2009, 121, 928-931

Lang S, Groth U (2009): Diastereoselective Formation of Cyclopropanols by a Chromium(II)-mediated Cross-coupling Reaction. Z. Naturforsch. 2009, 64b, 980 – 984

Mayer J, Cook AM (2009): Homotaurine metabolized to 3-sulfopropanoate in Cupriavidus necator H16: enzymes and genes in a patchwork pathway. J Bacteriol 2009, 191, 6052-6058

Muchamuel T / Basler M, Aujay MA, Suzuki E, Kalim KW, Lauer C, Sylvain C, Ring ER, Shields J, Jiang J, Shwonek P, Parlati F, Demo SD, Bennett MK, Kirk CJ, Groettrup M (2009): A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med 2009, 15, 781-787

Schildknecht S, Pöltl D, Nagel DM, Matt F, Scholz D, Lotharius J, Schmieg N, Salvo-Vargas A, Leist M (2009): Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicol Appl Pharm 2009, 241, 23-35

Vijay S, Azarkh M, Exner TE, Hartig JS, Drescher M (2009): Human Telomeric Quadruplex Conformations Studied by Pulsed EPR. Angew Chem Int Ed 2009, 48, 9728-9730 / Angew Chem 2009, 121, 9908–9910

Wieland M, Benz A, Klauser B, Hartig JS (2009): Artificial ribozyme switches containing natural riboswitch aptamer domains. Angew Chem Int Ed 2009, 48, 2715-2718

Wieland M, Gfell M, Hartig JS (2009): Expanded hammerhead ribozymes containing addressable three-way junctions. RNA 2009, 15, 968-976

Wieland M, Hartig JS (2009): Investigation of mRNA quadruplex formation in Escherichia coli. Nat Protoc 2009, 4, 1632-1640


Benz A, Hartig JS (2008): Redesigned tetrads with altered hydrogen bonding patterns enable programming of quadruplex topologies. Chem Commun 2008, 4010–4012

Denger K, Mayer J, Hollemeyer K, Cook AM (2008): Amphoteric surfactant N-oleoyl-N-methyltaurine utilized by Pseudomonas alcaligenes with excretion of N-methyltaurine. FEMS Microbiol Lett 2008, 288, 112-117

Iaroshenko VO, Groth U, Kryvokhyzha NV, Obeid S, Tolmachev AA, Wesch T (2008): A Practical Synthetic Route to Benzofuro[2,3-b]pyridine and Trifluoromethyl-α-carbolines. Synlett 2008, 343-346

Mayer J, Denger K, Kaspar K, Hollemeyer K, Smits THM, Huhn T, Cook AM (2008): Assimilation of homotaurine-nitrogen by Burkholderia sp. and excretion of sulfopropanoate. FEMS Microbiol Lett 2008, 279, 77–82

Obeid S, Yulikov M, Jeschke G, Marx A (2008): Enzymatic Synthesis of Multiple Spin-Labeled DNA. Angew Chem Int Ed 2008, 47, 6782–6785

Wesch T, Iaroshenko VO, Groth U (2008): A Convenient One-Pot Synthesis of 7-Trifluoromethyl-Substituted Imidazo[4,5-b]pyridines. Synlett 2008, 1459-1462

Wieland M, Hartig JS (2008): Artificial Riboswitches: Synthetic mRNA-Based Regulators of Gene Expression. ChemBioChem 2008, 9, 1873-1878